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Browse all issues →Digital Pulse — a monthly read on what’s new in the field
Latest issue: Digital Pulse — October 2026
Recent developments
Whole-Slide Imaging vs Light Microscopy: Establishing Noninferiority for Primary DiagnosisWhole-Slide Imaging vs Light Microscopy: Primary-Diagnosis Noninferiority: what the method does, the validation evidence, and where it stands. Evidence-basWeakly-Supervised Clinical-Grade Computational Pathology: The Slide Triage Use CaseWeakly-Supervised Clinical-Grade Computational Pathology (Slide Triage): what the method does, the validation evidence, and where it stands. Evidence-basedPaige Prostate: AI Cancer Detection on BiopsyPaige Prostate: AI Cancer Detection on Biopsy: what the method does, the validation evidence, and where it stands. Evidence-based, with primary citations.AI-Discovered Prognosis from the Glass Slide: The DoMore Deep-Learning Biomarker in Colorectal CancerDeep-Learning Prognostic Biomarker from H&E in Colorectal Cancer (DoMore): what the method does, the validation evidence, and where it stands. Evidence-basDeep-Learning Subtyping of Non–Small Cell Lung Cancer from H&E Whole-Slide ImagesDeep-Learning NSCLC Subtyping from H&E: what the method does, the validation evidence, and where it stands. Evidence-based, with primary citations.AI Quantification of Tumor Budding and Poorly Differentiated Clusters in Colorectal CancerAI Tumor-Budding / Poorly-Differentiated-Cluster Quantification in Colorectal Cancer: what the method does, the validation evidence, and where it stands. EAI Single-Cell Mismatch-Repair IHC Quantification in Colorectal CancerAI Single-Cell Mismatch-Repair IHC Quantification in Colorectal Cancer: what the method does, the validation evidence, and where it stands. Evidence-based,AI Histologic Grading of Breast Carcinoma: What "predGrade" Can and Cannot DoAI Histologic Grading of Breast Carcinoma (predGrade): what the method does, the validation evidence, and where it stands. Evidence-based, with primary citAI HER2 IHC Scoring in Breast Cancer: the HER2-0-vs-1+ ProblemAI HER2 IHC Scoring in Breast Cancer: the HER2-0-vs-1+ Problem: what the method does, the validation evidence, and where it stands. Evidence-based, with prAI Gleason Grading: The Generalizability Problem in Prostate PathologyAI Gleason Grading: Cross-Scanner and Cross-Population Generalization: what the method does, the validation evidence, and where it stands. Evidence-based, AI Gleason Grading: How Deep-Learning Systems Compare with Expert Uropathologists on Prostate BiopsiesAI Gleason Grading: Accuracy vs Uropathologists: what the method does, the validation evidence, and where it stands. Evidence-based, with primary citationsAI-Assisted Detection of Breast Cancer Lymph-Node Metastases: What Assistive Algorithms Add, and What They Don'tAI Breast Lymph-Node Metastasis Detection: what the method does, the validation evidence, and where it stands. Evidence-based, with primary citations.AI-Assist Uplift and Human-in-the-Loop Pathology: Does Help Actually Help?AI-Assist Uplift and Human-in-the-Loop Pathology: what the method does, the validation evidence, and where it stands. Evidence-based, with primary citationAn Image-Derived Risk Score Enters the HR+/HER2− Decision, and the Workflow Gets InterestingAI-based risk stratification entering HR+/HER2- early breast cancer: what the technology does, the evidence behind it, and where it stands. Evidence-based,Computational Ki-67 Quantification: Where Image Analysis Helps and Where It Doesn'tComputational Ki-67 quantification: where image analysis helps and where it doesn't: what the technology does, the evidence behind it, and where it stands.Reading the Regulatory Map: How FDA Clears AI in Pathology, and Why So Few Make It ThroughFDA regulatory frameworks for AI/ML Software as a Medical Device in pathology: what the technology does, the evidence behind it, and where it stands. EvideMultimodal AI Enters Prostate Prognosis: Inside the First FDA-Cleared ToolsFDA-cleared multimodal AI prognostic tools in localized prostate cancer: what the technology does, the evidence behind it, and where it stands. Evidence-baAI as First Reader: Pre-Screening Prostate and Breast BiopsiesAI-assisted cancer detection as a screening/pre-screen layer in prostate and breast biopsies: what the technology does, the evidence behind it, and where iScoring HER2 by Algorithm: Computational Analysis and the Ultralow ProblemComputational HER2 image analysis and the HER2-low/ultralow reproducibility problem: what the technology does, the evidence behind it, and where it stands.